Acetaldehyde → 2-chloroethanal O-[2-(morpholin-4-yl)ethyl]oxime

HRID 10171

反応式

HRID 10171 の反応式
[CH:1](=O)[CH3:2].[ClH:4].Cl.[N:6]1([CH2:12][CH2:13][O:14][NH2:15])[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1.[OH-].[Na+]>O>[N:6]1([CH2:12][CH2:13][O:14][N:15]=[CH:2][CH2:1][Cl:4])[CH2:11][CH2:10][O:9][CH2:8][CH2:7]1

参加物

5

反応物 3

HCID 177AcetaldehydeHCID 14798Sodium Hydroxide2 回HCID 21978765HCID 21978765、化合物

生成物 1

HCID 738572932-chloroethanal O-[2-(morpholin-4-yl)ethyl]oxime収率 100%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A mixture of acetaldehyde (0.1 mL of a 50 wt % soln. in water), O-[2-((morpholin-4-yl))ethyl]hydroxylamine dihydrochloride (0.14 g), NaOH (2N, 0.64 mL) and water (5 mL) was stirred at room temperature overnight. The solution was made basic with NaOH (1N) and extracted with dichloromethane. The organic layer was dried (Na2SO4), and concentrated in vacuo to afford 2-chloroethanal O-[2-((morpholin-4-yl))ethyl]oxime (0.13 g, ˜100%), which was used as such.

後処理

  1. extractionextracted with dichloromethane
  2. dry with materialThe organic layer was dried (Na2SO4)
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-43d79bad5eef413a95504b9e5c6de2be
出典データセット
uspto-grants-2006_08
特許番号
US07094779B2

関連ノート

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