8-Methylquinoline-5-carboxylic acid → 8-Methyl-1,2,3,4-tetrahydroquinoline-5-carboxylic acid

HRID 1017130ノート

反応式

HRID 1017130 の反応式
[CH3:1][C:2]1[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1.[H][H]>[Pd].C(O)C>[CH3:1][C:2]1[C:11]2[NH:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 129507838-Methylquinoline-5-carboxylic acidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 139517338-Methyl-1,2,3,4-tetrahydroquinoline-5-carboxylic acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

0.1 mol of 8-methylquinoline-5-carboxylic acid was suspended in 1.5 1 of ethanol and admixed with 10.0 g of palladium on activated carbon (5%). In an autoclave, the mixture was reduced at 50° C. with hydrogen (1 bar) over a period of 48 hours (HPLC monitoring). The reaction mixture was subsequently filtered, the filter cake was washed with ethanol and the combined organic filtrates were concentrated.

後処理

  1. filtrationThe reaction mixture was subsequently filtered
  2. washthe filter cake was washed with ethanol
  3. concentrationthe combined organic filtrates were concentrated

出典と根拠

ORDレコード
ord-ff2acbc3e664438e90c8f8519055686b
出典データセット
uspto-grants-2002_11
特許番号
US06479436B1

反応ノート

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