Methyl iodide → 5-methoxy-1-methyl-1H-indole

HRID 1017588

反応式

HRID 1017588 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[CH:6]2.[OH-].[K+].[CH3:14]I>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:14])[CH:7]=[CH:6]2

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 138725-MethoxyindoleHCID 14797Potassium Hydroxide

生成物 1

HCID 8198645-methoxy-1-methyl-1H-indole収率 82.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 5-methoxyindole (1 g, 6.8 mmol) in 8 mL of DMF were added potassium hydroxide (0.92 g, 2.4 eq.) and methyl iodide (1 mL, 16 mmol). The resulting mixture was stirred at room temperature overnight. After removing volatile, the residue was diluted with EtOAc and washed with water (4×). The organic layer was dried and concentrated to afford 0.9 g (82%) 5-methoxy-1-methylindole. MS (EI): (M++1) 162.

後処理

  1. customAfter removing volatile
  2. additionthe residue was diluted with EtOAc
  3. washwashed with water (4×)
  4. customThe organic layer was dried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-a42b9acf5e5147af8e98fb0c35a46f67
出典データセット
uspto-grants-2002_11
特許番号
US06479490B2

関連ノート

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