Methyl iodide → 5-methoxy-1-methyl-1H-indole
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[CH:6]2.[OH-].[K+].[CH3:14]I>CN(C=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH3:14])[CH:7]=[CH:6]2参加物
5
実験手順
To a solution of 5-methoxyindole (1 g, 6.8 mmol) in 8 mL of DMF were added potassium hydroxide (0.92 g, 2.4 eq.) and methyl iodide (1 mL, 16 mmol). The resulting mixture was stirred at room temperature overnight. After removing volatile, the residue was diluted with EtOAc and washed with water (4×). The organic layer was dried and concentrated to afford 0.9 g (82%) 5-methoxy-1-methylindole. MS (EI): (M++1) 162.
後処理
- customAfter removing volatile
- additionthe residue was diluted with EtOAc
- washwashed with water (4×)
- customThe organic layer was dried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-a42b9acf5e5147af8e98fb0c35a46f67
- 出典データセット
- uspto-grants-2002_11
- 特許番号
- US06479490B2
反応ノート
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