Water → acetophenone O-[2-((morpholin-4-yl))ethyl]oxime

HRID 10176

反応式

HRID 10176 の反応式
[C:1](=[N:9][OH:10])([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)[CH3:2].O.Cl.Cl[CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1.[OH-].[Na+]>C1(C)C=CC=CC=1.[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[N:16]1([CH2:15][CH2:14][O:10][N:9]=[C:1]([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH3:2])[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1

参加物

7

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 69185AcetophenonoximeHCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)

生成物 1

HCID 86594237acetophenone O-[2-((morpholin-4-yl))ethyl]oxime

試薬・触媒・溶媒 2

HCID 74236Tetrabutylammonium Bromide触媒HCID 1140Toluene溶媒

反応条件

温度
75 °C

実験手順

To a solution of acetophenone oxime (20 g) in toluene (700 mL) was added subsequently tetrabutylammonium bromide (4.77 g), water (8 mL), 4-(2-chloroethyl)morpholine hydrochloride (30.31 g) and finally 50% sodium hydroxide (aq, 52 mL). The resulting mixture was heated at 75° C. overnight. After cooling to room temperature water was added, to dissolve all the salts, the layers were separated, and the aqueous layer was extracted with toluene. The organic layers were dried (MgSO4), and concentrated in vacuo. The residue was purified by flash chromatography (SiO2, CH2Cl2/MeOH 95/5) to afford acetophenone O-[2-((morpholin-4-yl))ethyl]oxime as an oil. The obtained oil was dissolved in 6M HCl (aq, 500 mL) and heated under reflux for 5 hours and subsequently stirred overnight at room temperature. The mixture was extracted with ether and concentrated in vacuo. The residue was crystallized from ethanol, to afford O-[2-((morpholin-4-yl))ethyl]hydroxylamine dihydrochloride. 24.8 g (77%)

後処理

  1. additionwas added
  2. dissolutionto dissolve all the salts
  3. customthe layers were separated
  4. extractionthe aqueous layer was extracted with toluene
  5. dry with materialThe organic layers were dried (MgSO4)
  6. concentrationconcentrated in vacuo
  7. customThe residue was purified by flash chromatography (SiO2, CH2Cl2/MeOH 95/5)

出典と根拠

ORDレコード
ord-7cdc52eb0f104415883f65036a3b8c9b
出典データセット
uspto-grants-2006_08
特許番号
US07094779B2

関連ノート

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