HCID 178418361、化合物 → HCID 178486573、化合物

HRID 1017749ノート

反応式

HRID 1017749 の反応式
[NH:1]1[CH:5]=[C:4]([CH:6]2[C:14]3[C:9](=[C:10]([CH3:18])[C:11]([CH3:17])=[C:12]([O:15][CH3:16])[CH:13]=3)[CH:8](O)[CH2:7]2)[N:3]=[CH:2]1.[H][H]>C(O)C.Cl.[Pd]>[CH3:16][O:15][C:12]1[CH:13]=[C:14]2[C:9]([CH2:8][CH2:7][CH:6]2[C:4]2[N:3]=[CH:2][NH:1][CH:5]=2)=[C:10]([CH3:18])[C:11]=1[CH3:17]

参加物

6

反応物 2

HCID 178418361HCID 178418361、化合物HCID 178486576HCID 178486576、化合物

生成物 1

HCID 178486573HCID 178486573、化合物

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 313Hydrochloric Acid溶媒HCID 702Ethanol溶媒

実験手順

3-(1H-Imidazol-4-yl)-5-methoxy-6,7-dimethylindan-1-ol (0.29 g) is dissolved in the mixture of ethanol (30 ml) and concentrated hydrochloric acid (0.2 ml). The solution is hydrogenated at 50-55° C. with 10% palladium on carbon as catalyst until no more hydrogen is consumed. The mixture is filtered and the filtrate is evaporated to dryness. The residue is crystallized from the mixture of ethyl acetate and ethanol. M.p. of the hydrochloride salt is 174-177° C.

後処理

  1. customis consumed
  2. filtrationThe mixture is filtered
  3. customthe filtrate is evaporated to dryness
  4. customThe residue is crystallized from the mixture of ethyl acetate and ethanol
  5. customis 174-177° C.

出典と根拠

ORDレコード
ord-0c3feb80b17743559748952c902e3985
出典データセット
uspto-grants-2002_11
特許番号
US06479530B2

反応ノート

読み込み中…