Ethyl Acetate → HCID 75024269、化合物

HRID 1017761ノート

反応式

HRID 1017761 の反応式
[F:1][C:2]([F:39])([F:38])[C:3]1[CH:4]=[C:5]([CH2:13][O:14][CH:15]2[CH2:19][CH2:18][CH:17]([N:20](C(OCC3C=CC=CC=3)=O)[CH3:21])[CH:16]2[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.C(OCC)(=O)C>CO.[Pd]>[F:1][C:2]([F:38])([F:39])[C:3]1[CH:4]=[C:5]([CH2:13][O:14][CH:15]2[CH2:19][CH2:18][CH:17]([NH:20][CH3:21])[CH:16]2[C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1

参加物

5

反応物 2

HCID 8857Ethyl AcetateHCID 865848721-(SR)-(3,5-Bis(trifluoromethyl)phenyl)methoxy-2-(SR)-phenyl-3-(RS)-(N-(benzyloxycarbonyl)-N-methylamino) cyclopentane

生成物 1

HCID 75024269HCID 75024269、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 475 mg of the above 1-(SR)-(3,5-bis(trifluoromethyl)-phenyl)methoxy-2-(SR)-phenyl-3-(RS)-(N-(benzyloxycarbonyl)-N-methylamino) cyclopentane in 5 mL of 1:1 methanol: ethyl acetate was hydrogenated over 100 mg of 10% Pd/C for 2 hours. The reaction was filtered and concentrated to afford the title compound as an oil. Mass spec (NH3/CI): 418 (M+1).

後処理

  1. filtrationThe reaction was filtered
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-160cb8ea256f4f32bf40e67074a5f408
出典データセット
uspto-grants-2002_11
特許番号
US06479518B2

反応ノート

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