Sodium Hydroxide → 1-[[2alpha-(4-Fluorophenyl)-3beta-[[(R)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl]oxy]cyclopentane-1beta-yl]methyl]piperidine-3alpha-carboxylic acid

HRID 1017776ノート

反応式

HRID 1017776 の反応式
[F:1][C:2]([F:41])([F:40])[C:3]1[CH:4]=[C:5]([C@H:13]([O:15][C@H:16]2[CH2:20][CH2:19][C@@H:18]([CH2:21][N:22]3[CH2:27][CH2:26][CH2:25][C@@H:24]([C:28]([O:30]CC)=[O:29])[CH2:23]3)[C@@H:17]2[C:33]2[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=2)[CH3:14])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[OH-].[Na+]>CO>[F:12][C:9]([F:10])([F:11])[C:7]1[CH:6]=[C:5]([C@H:13]([O:15][C@H:16]2[CH2:20][CH2:19][C@@H:18]([CH2:21][N:22]3[CH2:27][CH2:26][CH2:25][C@@H:24]([C:28]([OH:30])=[O:29])[CH2:23]3)[C@@H:17]2[C:33]2[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=2)[CH3:14])[CH:4]=[C:3]([C:2]([F:41])([F:1])[F:40])[CH:8]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 228974321-(S)-(1-(R)-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-2-(R)-(4-fluorophenyl)-3-(R)-(((R)-3-ethoxycarbonylpiperidin-1-yl)methyl)cyclopentane

生成物 1

HCID 115993661-[[2alpha-(4-Fluorophenyl)-3beta-[[(R)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl]oxy]cyclopentane-1beta-yl]methyl]piperidine-3alpha-carboxylic acid収率 93.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 10.14 g (17.2 mmole) of 1-(S)-(1-(R)-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(R)-(4-fluorophenyl)-3-(R)-(((R)-3-ethoxycarbonylpiperidin-1-yl)methyl)cyclopentane from Step B in 100 mL of methanol was added 17.2 mL (86 mmole) of 5N sodium hydroxide. The reaction was stirred at rt for 20 hours and was then most of the methanol was removed in vacuo. The residue was diluted with water and the pH was adjusted to 7 with 2N hydrochloric acid. The mixture was extracted 3 times with methylene chloride and each organic layer was washed with a portion of brine. The organic layers were dried over sodium sulfate and evaporated to afford 9.0 g of crude title compound as a white foam. NMR (CDCl3)δ: 1.37 (d, J=6 Hz, 3H), 1-8-2.0 (m, 2H), 2.0-2.7 (m, 12H), 2.7-3.1 (m, 2H), 3.2-3.4 (1H), 3.4-3.6 (m, 2H), 3.69 (m, 1H), 4.48 (q, J=6 Hz, 1H), 6.96 (m, 1H), 7.11 (m, 1H), 7.40 (s, 2H), 7.69 (s, 1H).

後処理

  1. custommost of the methanol was removed in vacuo
  2. additionThe residue was diluted with water
  3. extractionThe mixture was extracted 3 times with methylene chloride
  4. washeach organic layer was washed with a portion of brine
  5. dry with materialThe organic layers were dried over sodium sulfate
  6. customevaporated

出典と根拠

ORDレコード
ord-4889c6ccc0b74b6d8b9d1dd33293be8a
出典データセット
uspto-grants-2002_11
特許番号
US06479518B2

反応ノート

読み込み中…