Diisopropylethylamine → 3-(5-{3-Methoxy-4-[3-(2-methylphenyl)ureido]-phenylacetylamino}pyrid-2-yl)-propanoic acid ethyl ester

HRID 1017992ノート

反応式

HRID 1017992 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:20][C:21]([OH:23])=O)[CH:6]=[CH:7][C:8]=1[NH:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:19])=[O:11].F[P-](F)(F)(F)(F)F.N1(OC(N(C)C)=[N+](C)C)C2N=CC=CC=2N=N1.C(N(C(C)C)CC)(C)C.[CH2:57]([O:59][C:60](=[O:70])[CH2:61][CH2:62][C:63]1[CH:68]=[CH:67][C:66]([NH2:69])=[CH:65][N:64]=1)[CH3:58]>CN(C)C=O>[CH2:57]([O:59][C:60](=[O:70])[CH2:61][CH2:62][C:63]1[CH:68]=[CH:67][C:66]([NH:69][C:21](=[O:23])[CH2:20][C:5]2[CH:6]=[CH:7][C:8]([NH:9][C:10]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH3:19])=[O:11])=[C:3]([O:2][CH3:1])[CH:4]=2)=[CH:65][N:64]=1)[CH3:58]

参加物

6

反応物 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 114498403-Methoxy-4-o-tolylureidophenylacetic acidHCID 23349309Ethyl 5-amino-2-pyridinepropanoate

生成物 1

HCID 541518273-(5-{3-Methoxy-4-[3-(2-methylphenyl)ureido]-phenylacetylamino}pyrid-2-yl)-propanoic acid ethyl ester収率 64.1%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

A solution of 3-methoxy-4-[3-(2-methylphenyl)ureido]phenylacetic acid (0.7 g, Reference Example 31) in anhydrous dimethylformamide (25 ml) was treated sequentially with O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (0.85 g), diisopropylethylamine (0.54 g) and a solution of 3-(5-amino-pyrid-2-yl)propanoic acid ethyl ester [0.42 g, Reference Example 4(a)] in dimethylformamide (5 ml). After stirring at room temperature for 5 hours and standing over night the reaction mixture was evaporated. The residue was treated with ethyl acetate and the resulting solution was washed three times with water, then with brine and then evaporated. The residue was subjected to flash chromatography on silica gel eluting with a mixture of dichloromethane and methanol (97:3, v/v) to give the title compound (0.68 g) as a white foam.

後処理

  1. waitstanding over night
  2. customthe reaction mixture was evaporated
  3. additionThe residue was treated with ethyl acetate
  4. washthe resulting solution was washed three times with water
  5. customwith brine and then evaporated
  6. additionThe residue was subjected to flash chromatography on silica gel eluting with a mixture of dichloromethane and methanol (97:3

出典と根拠

ORDレコード
ord-f4a9464f0be74e7daced5d6f7269d95a
出典データセット
uspto-grants-2002_11
特許番号
US06479519B1

反応ノート

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