Methanol → 6-(Methoxycarbonyl)pyridine-3-carboxylic acid

HRID 1018013

反応式

HRID 1018013 の反応式
[N:1]1[CH:6]=[C:5]([C:7]([OH:9])=[O:8])[CH:4]=[CH:3][C:2]=1[C:10]([OH:12])=[O:11].[CH3:13]O.S(=O)(=O)(O)O>O>[CH3:13][O:11][C:10]([C:2]1[CH:3]=[CH:4][C:5]([C:7]([OH:9])=[O:8])=[CH:6][N:1]=1)=[O:12]

参加物

5

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 74932,5-Pyridinedicarboxylic acid

生成物 1

HCID 5796316-(Methoxycarbonyl)pyridine-3-carboxylic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of pyridine-2,5-dicarboxylic acid (8.4 g), methanol (100 ml) and concentrated sulphuric acid (1.7 ml) was heated at reflux for 2 hours, cooled and poured into water (11). The resultant precipitate was collected and recrystallised from ethanol to give the title compound as a white solid, m.p. 222-223° C.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours
  3. temperaturecooled
  4. customThe resultant precipitate was collected
  5. customrecrystallised from ethanol

出典と根拠

ORDレコード
ord-45d8ce59bfa7458b874a7caa5c6d8d35
出典データセット
uspto-grants-2002_11
特許番号
US06479519B1

関連ノート

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