Water → 3-[(5-Cycloheptylmethyl-2-o-tolyl-1H-imidazole-4-carbonyl)-amino]-benzoic Acid
反応式
[C:1]1([CH3:9])[C:2]([CH:7]=O)=[CH:3][CH:4]=[CH:5][CH:6]=1.C([O:17][C:18](=[O:26])[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([NH2:25])[CH:20]=1)C1C=CC=CC=1.C(OC(=O)C1[CH:51]=[C:50]([NH2:52])C=C(C(OCC2C=CC=CC=2)=O)C=1)C1C=CC=CC=1.[CH3:54][NH:55][CH2:56][C@@H:57]([C@H:59]([C@@H:61]([C@@H:63]([CH2:65]O)O)O)O)O.[OH2:67].O.O1CCO[CH2:71][CH2:70]1>>[CH:2]1([CH2:7][C:54]2[NH:55][C:56]([C:57]3[CH:59]=[CH:61][CH:63]=[CH:65][C:70]=3[CH3:71])=[N:52][C:50]=2[C:51]([NH:25][C:21]2[CH:20]=[C:19]([CH:24]=[CH:23][CH:22]=2)[C:18]([OH:17])=[O:26])=[O:67])[CH2:1][CH2:9][CH2:6][CH2:5][CH2:4][CH2:3]1参加物
7
実験手順
The title compound was prepared according to the procedure of Example 20, with the modification that o-tolualdehyde was used instead of 2-naphthaldehyde in step b, and 3-amino-benzoic acid benzyl ester replaced 5-amino-isophthalic acid dibenzyl ester in step d. 1H NMR (300 MHz, d6-DMSO) 13.00 (1H, br s), 12.52 (1H, br s), 9.78 (1H, s), 8.51 (1H, s), 7.93 (1H, m), 7.60 (2H, m), 7.41 (1H, t), 7.32 (3H, m), 2.93 (2H, d), 2.54 (3H, s), 2.00 (1H, m), 1.66-1.22 (12H, m). The acid was converted to the N-methyl-D-glucamine salt and lyophilised from water/dioxan. Found: C, 60.05; H, 7.70; N, 8.46%. C33H46N4O8.1.9 mols H2O requires: C, 60.03; H, 7.59; N, 8.49%.
出典と根拠
- ORDレコード
- ord-fd134e0423804823aa9d45b14819109b
- 出典データセット
- uspto-grants-2002_11
- 特許番号
- US06479531B1
反応ノート
読み込み中…