Thionyl Chloride → HCID 12011185、化合物

HRID 1018504ノート

反応式

HRID 1018504 の反応式
S(Cl)([Cl:3])=O.[Cl:5][C:6]1[CH:21]=[CH:20][CH:19]=[CH:18][C:7]=1[CH2:8][N:9]1[C:13]([CH3:14])=[C:12]([CH3:15])[N:11]=[C:10]1[CH2:16]O>>[Cl:5][C:6]1[CH:21]=[CH:20][CH:19]=[CH:18][C:7]=1[CH2:8][N:9]1[C:13]([CH3:14])=[C:12]([CH3:15])[N:11]=[C:10]1[CH2:16][Cl:3]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 12011184HCID 12011184、化合物

生成物 1

HCID 12011185HCID 12011185、化合物

反応条件

温度
50 °C

実験手順

To 3 ml of thionyl chloride is added 2.39 g (9.5 mmol) of 1- (2-chlorobenzyl)-4,5 dimethyl-2-hydroxymethylimidazole. The mixture is heated at 50° C. for about 5 min., and the thionyl choride is evaporated in vacuo. The residue is then dissolved in 10 ml of dichloromethane, and subsequently evaporated in vacuo. This is repeated twice to give 1-(2-chlorobenzyl)-4,5-dimethyl-2-chloromethylimidazole (4) as a cream colored foam which is used without further purification.

後処理

  1. customthe thionyl choride is evaporated in vacuo
  2. dissolutionThe residue is then dissolved in 10 ml of dichloromethane
  3. customsubsequently evaporated in vacuo

出典と根拠

ORDレコード
ord-329cf04769e3468c870b7ce4572947e3
出典データセット
uspto-grants-2002_11
特許番号
US06482844B1

反応ノート

読み込み中…