Hydrochloric Acid → HCID 18401893、化合物

HRID 1018662ノート

反応式

HRID 1018662 の反応式
[CH:1]1([CH2:7][O:8][C:9]2[CH:10]=[CH:11][C:12]3[C:18](=[O:19])[CH2:17][CH2:16][CH2:15][CH2:14][C:13]=3[CH:20]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[BH4-].[Na+].Cl>CCO>[CH:1]1([CH2:7][O:8][C:9]2[CH:10]=[CH:11][C:12]3[CH:18]([OH:19])[CH2:17][CH2:16][CH2:15][CH2:14][C:13]=3[CH:20]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 10707356HCID 10707356、化合物

生成物 1

HCID 18401893HCID 18401893、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
40 °C

実験手順

To a suspension of 2-cyclohexylmethoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one (14.5 g, 53.23 mmol) in EtOH (150 mL) was added NaBH4 (1.96 g, 53.23 mmol) portionwise over 10 min. The mixture was heated to 40° C. for 1 h, cooled to 0° C., then made acidic with the addition of 1 N HCl. The white precipated solids were filtered, washed with water, and dried in vacuuo (14.25 g, 97%). m.p. 102-103° C.

後処理

  1. temperaturecooled to 0° C.
  2. filtrationThe white precipated solids were filtered
  3. washwashed with water
  4. customdried in vacuuo (14.25 g, 97%)

出典と根拠

ORDレコード
ord-314d397d5877494c97ff8a4b6e610389
出典データセット
uspto-grants-2002_11
特許番号
US06482852B2

反応ノート

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