HCID 178418361、化合物 → HCID 178430523、化合物
反応式
[C:1]([C:3]1[C:8]2[N:9]=[CH:10][NH:11][C:7]=2[C:6]([CH3:12])=[C:5]([N+:13]([O-])=O)[CH:4]=1)#[N:2].[H][H]>CO.[Pd]>[NH2:13][C:5]1[CH:4]=[C:3]([C:1]#[N:2])[C:8]2[N:9]=[CH:10][NH:11][C:7]=2[C:6]=1[CH3:12]参加物
5
実験手順
A mixture of 7-cyano-4-methyl-5-nitrobenzimidazole (0.91 g, 4.5 mmol) and 10% palladium-on-carbon (100 mg) in methanol (200 mL) is treated with an atmosphere of hydrogen (1 atm, balloon) for 14 hours. The resulting mixture is filtered through Celite and rotary evaporated. The residue is purified by flash chromatography (silica gel, 95:5 ethyl acetate:methanol) to afford 5-amino-7-cyano-4-methylbenzimidazole.
後処理
- filtrationThe resulting mixture is filtered through Celite and rotary evaporated
- customThe residue is purified by flash chromatography (silica gel, 95:5 ethyl acetate:methanol)
出典と根拠
- ORDレコード
- ord-8fea9ded25904dafb16cf66c47b89271
- 出典データセット
- uspto-grants-2002_11
- 特許番号
- US06486190B1
反応ノート
読み込み中…