反応式
C(O)CC=C.C=CC=C.C([O-])(=O)C=CC=C.[C:17](SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@@H](N2C3N=CN=C(N)C=3N=C2)[C@H](O)[C@@H]1OP(O)(O)=O)(=[O:22])[CH2:18][C:19]([OH:21])=[O:20].[C:71]([S:74][CH2:75][CH2:76][NH:77][C:78](=[O:121])[CH2:79][CH2:80][NH:81][C:82](=[O:120])[C@H:83]([OH:119])[C:84]([CH3:118])([CH3:117])[CH2:85][O:86][P:87]([OH:116])(=[O:115])[O:88][P:89]([OH:114])(=[O:113])[O:90][CH2:91][C@H:92]1[O:96][C@@H:95]([N:97]2[C:106]3[N:105]=[CH:104][N:103]=[C:101]([NH2:102])[C:100]=3[N:99]=[CH:98]2)[C@H:94]([OH:107])[C@@H:93]1[O:108][P:109]([OH:112])([OH:111])=[O:110])(=[O:73])[CH3:72]>>[O:22]=[C:17]([CH2:18][C:19]([OH:21])=[O:20])[CH2:72][C:71]([S:74][CH2:75][CH2:76][NH:77][C:78](=[O:121])[CH2:79][CH2:80][NH:81][C:82](=[O:120])[C@H:83]([OH:119])[C:84]([CH3:117])([CH3:118])[CH2:85][O:86][P:87]([OH:116])(=[O:115])[O:88][P:89]([OH:114])(=[O:113])[O:90][CH2:91][C@H:92]1[O:96][C@@H:95]([N:97]2[C:106]3[N:105]=[CH:104][N:103]=[C:101]([NH2:102])[C:100]=3[N:99]=[CH:98]2)[C@H:94]([OH:107])[C@@H:93]1[O:108][P:109]([OH:112])([OH:111])=[O:110])=[O:73]参加物
実験手順
Pathways to 3-butene-1-ol, butadiene and 2,4-pentadienoate from malonyl-CoA and acetyl-CoA are shown in FIG. 21. In these pathways, malonyl-CoA and acetyl-CoA are joined by a thiolase to form 3-oxoglutaryl-CoA. This intermediate can then be converted to 3,5-dihydroxypentanoate by several alternate routes (Steps B/C/D, Steps B/G, Steps H/I/J, Steps H/L/D, K/J). Once formed, 3,5-dihydroxypentanoate can be decarboxylated by a 3-hydroxyacid decarboxylase to form 3-butene-1-ol (Step M). Subsequent dehydration by a 3-butene-1-ol dehydrogenase or a chemical catalyst yields butadiene (Step O). Alternately, 3,5-dihydroxypentanoate can be dehydrated to 5-hydroxypent-2-enoate as shown in Step E. This intermediate can then be decarboxylated to 3-butene-1-ol (Step N) or further dehydrated to 2,4-pentadienoate (Step F).
出典と根拠
- ORDレコード
- ord-6c55b5697992423b96a698721edb17eb
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08715957B2
関連ノート
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