Water → 2-Chloro-5-methoxy-4-nitrobenzoic acid

反応式

[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([O:11][CH3:12])=[CH:4][C:3]=1[CH3:13].[Mn]([O-])(=O)(=O)=[O:15].[K+].[OH2:20]>>[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[C:5]([O:11][CH3:12])=[CH:4][C:3]=1[C:13]([OH:15])=[O:20]

参加物

反応物 3

HCID 962Water

HCID 516875Potassium Permanganate

HCID 158645661-Chloro-4-methoxy-2-methyl-5-nitrobenzene

生成物 1

HCID 580563702-Chloro-5-methoxy-4-nitrobenzoic acid収率 78%

実験手順

A solution of 1-chloro-4-methoxy-2-methyl-5-nitrobenzene (1 mmol) and potassium permanganate (4 mmol) in water (100 mL) was heated at reflux temperature for 48 hours. The mixture was allowed to cool to room temperature and the pH was adjusted 2. The solution was extracted with EtOAc (2×100 mL), then the combined organic extracts was dried (Na2SO4) and concentrated under reduced pressure to give the title compound (78%) as a solid.