反応式
Cl[CH2:2][CH2:3][CH2:4][S:5]([NH:8][CH3:9])(=[O:7])=[O:6].[N-:10]=[N+:11]=[N-:12].[Na+]>CN(C=O)C.[Cl-].[Na+].O>[N:10]([CH2:2][CH2:3][CH2:4][S:5]([NH:8][CH3:9])(=[O:7])=[O:6])=[N+:11]=[N-:12]参加物
5
反応条件
- 温度
- 100 °C
実験手順
A mixture of 3-chloro-N-methylpropane-1-sulfonamide (29 mmol), NaN3 (29 mmol) in DMF (50 ml) was stirred at 100° C. for 2 h. The mixture was poured into 40 ml of brine. The mixture was extracted with ether (3×30 ml). The organic layers were combined and washed with 20 ml of brine. The organic layer was dried with Na2SO4, filtered and the filtrate was evaporated. Yield: 4.2 g (90% purity, 81% yield).
後処理
- extractionThe mixture was extracted with ether (3×30 ml)
- washwashed with 20 ml of brine
- dry with materialThe organic layer was dried with Na2SO4
- filtrationfiltered
- customthe filtrate was evaporated
出典と根拠
- ORDレコード
- ord-7327b5353c674b6295c48d1cd2618630
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08716293B2
関連ノート
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