Hippuric Acid → 2-Carboxymethylbenzaldehyde hippuric acid

HRID 1020010ノート

反応式

HRID 1020010 の反応式
[C:1]([CH2:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8])([OH:3])=[O:2].[C:13]([OH:25])(=[O:24])[CH2:14][NH:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:17].C([O-])(=O)C.[K+].C(OC(=O)C)(=O)C>O>[C:13]([OH:25])(=[O:24])[CH2:14][NH:15][C:16]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)=[O:17].[C:1]([CH2:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH:7]=[O:8])([OH:3])=[O:2]

参加物

6

反応物 4

HCID 464Hippuric AcidHCID 7918Acetic AnhydrideHCID 517044Potassium AcetateHCID 5289058Ortho-formylphenylacetic acid

生成物 1

HCID 866643832-Carboxymethylbenzaldehyde hippuric acid収率 83%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

2-Carboxymethylbenzaldehyde (4.9 g, and 30 mmoles) with hippuric acid (5.9 g, 33 moles) and potassium acetate (2.94 g, 30 mmoles) were added to acetic anhydride (14.2 mls, 150 mmoles) and the reaction heated (100° C.) for 4 hours. To the cooled reaction was added water (100 mls) and stirred overnight. The resulting solid was collected by filtration and washed with water and dried (7.6 g, 83% yield).

後処理

  1. customTo the cooled reaction
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed with water
  4. customdried (7.6 g, 83% yield)

出典と根拠

ORDレコード
ord-4a4960fcc1c545198d1acb95e8f49687
出典データセット
uspto-grants-2014_05
特許番号
US08716302B2

反応ノート

読み込み中…