Sodium Iodide → HCID 58055059、化合物

HRID 1020252ノート

反応式

HRID 1020252 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15]Cl)[N:14]=1)=[O:8].[Na+].[I-:22]>CC(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][I:22])[N:14]=1)=[O:8]

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 58055096HCID 58055096、化合物

生成物 1

HCID 58055059HCID 58055059、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 1-(3,4-dichlorobenzyl)-3-(4-(chloromethyl)thiazol-2-yl)urea (1 eq) in acetone was added NaI (10 eq) at once. The mixture was stirred at room temperature for 2 h. The volatiles were removed in vacuo and the mixture was taken up in water and EtOAc. The layers were separated and the organic phase was partitioned with water and then brine, dried over Na2SO4, filtered, and concentrated in vacuo to afford 1-(3,4-dichlorobenzyl)-3-(4-(iodomethyl)thiazol-2-yl)urea as a tan-colored solid in near quantitative yield.

後処理

  1. customThe volatiles were removed in vacuo
  2. customThe layers were separated
  3. customthe organic phase was partitioned with water
  4. dry with materialbrine, dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-8c1b86b5c80a4221ad823633a1a6d3f4
出典データセット
uspto-grants-2014_05
特許番号
US08716320B2

反応ノート

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