Sodium Hydroxide → 2-(3-(3,4-Dichlorobenzyl)ureido)thiazole-4-carboxylic acid

HRID 1020265ノート

反応式

HRID 1020265 の反応式
[OH-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([CH:22]=[CH:23][C:24]=1[Cl:25])[CH2:7][NH:8][C:9](=[O:21])[NH:10][C:11]1[S:12][CH:13]=[C:14]([C:16]([O:18]CC)=[O:17])[N:15]=1>C(O)C>[Cl:3][C:4]1[CH:5]=[C:6]([CH:22]=[CH:23][C:24]=1[Cl:25])[CH2:7][NH:8][C:9](=[O:21])[NH:10][C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 86622748Ethyl 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylate

生成物 1

HCID 866227642-(3-(3,4-Dichlorobenzyl)ureido)thiazole-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Sodium hydroxide (24 mL, 24 mmol, 1N in water) was added to an ethanol (50 mL) solution of ethyl 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylate (Example 38) (1.8 g, 4.8 mmol). The mixture was stirred overnight. The ethanol was removed by evaporation and the aqueous solution was filtered then the filter was washed with water (20 ml). The pH of the filtrate was adjusted to less than three with concentrated HCl. The precipitate was filtered, washed with water and dried to afford 2-(3-(3,4-dichlorobenzyl)ureido)thiazole-4-carboxylic acid.

後処理

  1. customThe ethanol was removed by evaporation
  2. filtrationthe aqueous solution was filtered
  3. washthe filter was washed with water (20 ml)
  4. filtrationThe precipitate was filtered
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-c18c43db4e9044b3bab7eb91dc18b865
出典データセット
uspto-grants-2014_05
特許番号
US08716320B2

反応ノート

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