Hydroxyamine hydrochloride → 1,2,3,3a,8,8a-Hexahydroindeno[1,2-c]pyrrole
反応式
C([O-])(=O)C.[Na+].Cl.[NH2:7]O.[C:9]1(=O)[CH:12]2[CH2:13][C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:19]=3[CH:11]2[CH2:10]1>CO>[CH2:9]1[NH:7][CH2:10][CH:11]2[C:19]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[CH2:13][CH:12]12参加物
5
実験手順
Sodium acetate (1.45 g, 17.7 mmol) and hydroxylamine hydrochloride (0.68 g, 9.75 mmol) were added to a solution of 2,2a,7,7a-tetrahydro-cyclobuta[a]inden-1-one (1.4 g, 8.86 mmol) in MeOH (18 mL), and stirred overnight at room temperature. The reaction solution was concentrated via rotary evaporation. The residue was dissolved in CH2Cl2 (100 mL), washed with H2O (50 mL), dried over MgSO4, and concentrated to give the subtitle compound, which was used without further purification. MS calculated for C11H11NO+H: 174, observed: 174.
後処理
- concentrationThe reaction solution was concentrated via rotary evaporation
- dissolutionThe residue was dissolved in CH2Cl2 (100 mL)
- washwashed with H2O (50 mL)
- dry with materialdried over MgSO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-38a132b8f60f4901b066e54b9d87ad02
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08716324B2
反応ノート
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