Methylamine → 6-Bromo-N-methylquinoxalin-2-amine

HRID 1020739ノート

反応式

HRID 1020739 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7](Cl)[CH:6]=[N:5]2.[CH3:13][NH2:14]>C1COCC1>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:14][CH3:13])[CH:6]=[N:5]2

参加物

4

反応物 2

HCID 6329MethylamineHCID 126864086-Bromo-2-chloroquinoxaline

生成物 1

HCID 601459936-Bromo-N-methylquinoxalin-2-amine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To solution of 6-bromo-2-chloro-quinoxaline (0.7 g, 1 eq, 2.87 mmol) in THF (6 mL) was added a solution of methyl amine in THF (3 mL) at room temperature. The mixture was stirred at room temperature for 2 h. After completion of the reaction, the volatiles were removed under vacuum and water (20 mL) was added to reaction mixture. The aqueous layer was extracted with ethyl acetate (15 mL×3). The organic layer was washed with water (20 mL) and brine (20 mL) and then dried over Na2SO4. The organic layer was concentrated under vacuum to afford the crude product.

後処理

  1. customAfter completion of the reaction
  2. customthe volatiles were removed under vacuum and water (20 mL)
  3. additionwas added to reaction mixture
  4. extractionThe aqueous layer was extracted with ethyl acetate (15 mL×3)
  5. washThe organic layer was washed with water (20 mL) and brine (20 mL)
  6. dry with materialdried over Na2SO4
  7. concentrationThe organic layer was concentrated under vacuum

出典と根拠

ORDレコード
ord-56e1df7a9b4f44b58b10a8ddb77ea8c2
出典データセット
uspto-grants-2014_05
特許番号
US08716473B2

反応ノート

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