Sodium Hydroxide → Sodium salt

HRID 1020778ノート

反応式

HRID 1020778 の反応式
[OH-].[Na+:2].[CH3:3][C:4]([C:7]1[CH:8]=[CH:9][C:10]([S:13]([NH:16][C:17]2[C:18]([O:33][C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][C:39]=3[O:40][CH3:41])=[C:19]([O:29][CH2:30][CH2:31][OH:32])[N:20]=[C:21]([C:23]3[N:24]=[CH:25][CH:26]=[CH:27][N:28]=3)[N:22]=2)(=[O:15])=[O:14])=[CH:11][CH:12]=1)([CH3:6])[CH3:5]>CO.ClCCl.C(OCC)(=O)C>[CH3:6][C:4]([C:7]1[CH:12]=[CH:11][C:10]([S:13]([N-:16][C:17]2[C:18]([O:33][C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][C:39]=3[O:40][CH3:41])=[C:19]([O:29][CH2:30][CH2:31][OH:32])[N:20]=[C:21]([C:23]3[N:28]=[CH:27][CH:26]=[CH:25][N:24]=3)[N:22]=2)(=[O:14])=[O:15])=[CH:9][CH:8]=1)([CH3:3])[CH3:5].[Na+:2]

参加物

6

反応物 2

HCID 14798Sodium HydroxideHCID 104865Bosentan

生成物 1

HCID 44387533Sodium salt

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Sodium hydroxide (0.44 g) was added to a mixture of bosentan (5 g) in methanol (10 mL), dichloromethane (2.5 mL) and ethyl acetate (40 mL). The reaction mixture was stirred for 3.5 hours at 20° C. to 25° C. and the solid was filtered to obtain the title compound.

後処理

  1. filtrationthe solid was filtered

出典と根拠

ORDレコード
ord-7feb390475a2452f9266f708c289d83b
出典データセット
uspto-grants-2014_05
特許番号
US08716477B2

反応ノート

読み込み中…