Methanol → 4-Methoxy-1H-pyrrolo[2,3-b]pyridine

HRID 1020905ノート

反応式

HRID 1020905 の反応式
[OH-:1].[Na+].Cl[C:4]1[CH:12]=[CH:11][N:10]=[C:9]2[C:5]=1[CH:6]=[CH:7][NH:8]2.[CH3:13]O>>[CH3:13][O:1][C:4]1[CH:12]=[CH:11][N:10]=[C:9]2[C:5]=1[CH:6]=[CH:7][NH:8]2

参加物

4

反応物 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 113894934-Chloro-1H-pyrrolo[2,3-b]pyridine

生成物 1

HCID 112405674-Methoxy-1H-pyrrolo[2,3-b]pyridine

実験手順

A solution of sodium hydroxide (11 g) in methanol (250 mL) was stirred with 4-chloro-1H-pyrrolo[2,3-b]pyridine (step 2)(12.2 g, 80 mmol) at 140° C. in a sealed reactor for 16 hr. After being cooled to ambient temperature the mixture was concentrated and residue was slurred in water (100 mL) for one hour. The solid was collected by suction filtration and washed to neutrality with water. After being dried to constant weight, 6.5 g of 4-methoxy-7-azaindole was obtained as a tan solid; MS (m/z) 149 (M+H).

後処理

  1. concentrationwas concentrated
  2. filtrationThe solid was collected by suction filtration
  3. washwashed
  4. customAfter being dried to constant weight

出典と根拠

ORDレコード
ord-6d758ae00c394184803892307e5fcb4f
出典データセット
uspto-grants-2014_05
特許番号
US08716493B2

反応ノート

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