Sodium Hydroxide → HCID 67273211、化合物

HRID 1020918ノート

反応式

HRID 1020918 の反応式
C1(S([N:10]2[C:18]3[C:13](=[C:14]([O:21][CH3:22])[C:15]([O:19][CH3:20])=[CH:16][CH:17]=3)[CH:12]=[C:11]2[C:23]2[CH2:27][CH2:26][CH2:25][CH:24]=2)(=O)=O)C=CC=CC=1.[OH-].[Na+]>CCO>[C:23]1([C:11]2[NH:10][C:18]3[C:13]([CH:12]=2)=[C:14]([O:21][CH3:22])[C:15]([O:19][CH3:20])=[CH:16][CH:17]=3)[CH2:27][CH2:26][CH2:25][CH:24]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 67273154HCID 67273154、化合物

生成物 1

HCID 67273211HCID 67273211、化合物収率 97.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To 291 mg (0.76 mmol) of the phenylsulfonamide intermediate from step 3 in 50 mL EtOH was added 5 mL 10% NaOH solution. The reaction was heated to reflux overnight and then concentrated. The residue was dissolved in EtOAc, washed with 2N Na2CO3 solution, H2O, aqueous NaCl solution, dried (MgSO4), and concentrated under vacuum to yield 180 mg of 2-cyclopent-1-enyl-4,5-dimethoxy-1H-indole (97%).

後処理

  1. temperatureThe reaction was heated
  2. temperatureto reflux overnight
  3. concentrationconcentrated
  4. dissolutionThe residue was dissolved in EtOAc
  5. washwashed with 2N Na2CO3 solution, H2O, aqueous NaCl solution
  6. dry with materialdried (MgSO4)
  7. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-db94dbbd12de40a491c48efc13c09c28
出典データセット
uspto-grants-2014_05
特許番号
US08716493B2

反応ノート

読み込み中…