Isobutylene → 4-Penten-2-ol, 1,1,1-trifluoro-4-methyl-2-(trifluoromethyl)-
反応式
[F:1][C:2]([F:10])([F:9])[C:3]([C:5]([F:8])([F:7])[F:6])=[O:4].[CH3:11][C:12](=[CH2:14])[CH3:13].C(=O)=O.CC(O)C>>[F:1][C:2]([F:10])([F:9])[C:3]([C:5]([F:8])([F:7])[F:6])([OH:4])[CH2:13][C:12]([CH3:14])=[CH2:11]参加物
4
反応条件
- 温度
- 20 °C
実験手順
Hexafluoroacetone (238 g) and 120 g of isobutylene were condensed into a lecture bottle using Dry Ice/2-propanol cooling. The temperature was raised in the sealed vessel to 20° C. while stirring in a water bath and temperature maintained overnight. The next morning the temperature was raised to 50° C. for 2 hours. After cooling, excess isobutylene was bled off and the product distilled at 100-115° C. to afford 264 g (83%) of a clear liquid. The identity of the product was confirmed using 1H NMR spectroscopy and HRMS.
後処理
- customcondensed into a lecture bottle
- temperaturetemperature maintained overnight
- temperatureThe next morning the temperature was raised to 50° C. for 2 hours
- temperatureAfter cooling
- distillationthe product distilled at 100-115° C.
出典と根拠
- ORDレコード
- ord-ec229910334e4f30804235521931f2f7
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08716534B2
反応ノート
読み込み中…