Trifluoroacetic acid → 2-(4-Chloro-phenyl)-2-methoxy-ethylamine

HRID 1021546ノート

反応式

HRID 1021546 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:18][CH3:19])[CH2:9][NH:10]C(=O)OC(C)(C)C)=[CH:4][CH:3]=1.FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([O:18][CH3:19])[CH2:9][NH2:10])=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67080810HCID 67080810、化合物

生成物 1

HCID 532762402-(4-Chloro-phenyl)-2-methoxy-ethylamine収率 84.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of tert-butyl 2-(4-chlorophenyl)-2-methoxyethylcarbamate (0.129 g, 0.451 mmol) in dichloromethane (5 ml) was added trifluoroacetic acid (5 ml), and the reaction was stirred at ambient temperature for 16 hours. The reaction was concentrated and taken up in water. Sodium hydroxide (1M) was added until the pH was >13. The mixture was extracted twice with dichloromethane, and the combined organic layers were dried over anhydrous sodium sulfate, filtered, and concentrated to yield 71 mg of the title compound (84.7% yield).

後処理

  1. concentrationThe reaction was concentrated
  2. additionSodium hydroxide (1M) was added until the pH was >13
  3. extractionThe mixture was extracted twice with dichloromethane
  4. dry with materialthe combined organic layers were dried over anhydrous sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-146b2d051d4240efb0d695b8acd43309
出典データセット
uspto-grants-2014_05
特許番号
US08716498B2

反応ノート

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