5-(Methylsulfonyl)-2-nitropyridine → 5-Methanesulfonylpyridin-2-amine
反応式
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([N+:11]([O-])=O)=[N:9][CH:10]=1)(=[O:4])=[O:3]>CO.[Pd]>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([NH2:11])=[N:9][CH:10]=1)(=[O:4])=[O:3]参加物
4
反応条件
- 温度
- 25 °C
実験手順
A mixture of 117b (2 g, 10 mmol), MeOH (10 mL), Pd/C (120 mg) in methanol (8 mL) was stirred fat 25° C. under H2 (50 Psi) overnight. The Pd/C was removed by filtration and the filtrate was concentrated under reduced pressure to give 117c (1.7 g, 98%). MS: [M+H]+ 173.
後処理
- customThe Pd/C was removed by filtration
- concentrationthe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-b198043baae040299949b2ebe3710df2
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08716274B2
反応ノート
読み込み中…