5-Ethyl-2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine → 5-Ethyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-amine
反応式
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]2[N:9]=[C:10]([N+:12]([O-])=O)[CH:11]=[C:5]2[CH2:4]1)[CH3:2].[H][H]>[Pd].CO>[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]2[N:9]=[C:10]([NH2:12])[CH:11]=[C:5]2[CH2:4]1)[CH3:2]参加物
5
実験手順
A 50-mL single-neck round-bottomed flask was purged with nitrogen and charged with 208a (1.4 g, 7.1 mmol), 10% palladium on carbon (50% wet, 208 mg), methanol (30 mL), and hydrogen gas. The mixture was stirred at room temperature under hydrogen atmosphere for 2 h. The catalyst was removed by filtration through a pad of CELITE® and the filtrate was concentrated under reduced pressure to afford 208b (1.0 g, 84%) as yellow oil. MS-ESI: [M+H]+ 167
後処理
- customA 50-mL single-neck round-bottomed flask was purged with nitrogen
- customThe catalyst was removed by filtration through a pad of CELITE®
- concentrationthe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-d813d6f76b264e80994b50df7e12d4a6
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08716274B2
反応ノート
読み込み中…