1-(2-Nitro-6,7-dihydropyrazolo[1,5-a]pyrazin-5(4H)-yl)propan-1-one → 1-{2-amino-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazin-5-yl}propan-1-one

HRID 1022094ノート

反応式

HRID 1022094 の反応式
[N+:1]([C:4]1[CH:16]=[C:7]2[CH2:8][N:9]([C:12](=[O:15])[CH2:13][CH3:14])[CH2:10][CH2:11][N:6]2[N:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:16]=[C:7]2[CH2:8][N:9]([C:12](=[O:15])[CH2:13][CH3:14])[CH2:10][CH2:11][N:6]2[N:5]=1

参加物

4

反応物 1

HCID 866845021-(2-Nitro-6,7-dihydropyrazolo[1,5-a]pyrazin-5(4H)-yl)propan-1-one

生成物 1

HCID 866845031-{2-amino-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazin-5-yl}propan-1-one収率 99.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 265a (260 mg, 1.16 mmol) in methanol (10 mL) was added 10% Pd/C (26 mg). The system was evacuated and then refilled with H2. After stirring for 2 h, analysis of the reaction mixture by LCMS showed complete conversion to the desired product. The mixture was filtered, and the filtrate was concentrated under reduced pressure to afford 265b as a yellow solid (225 mg, 99%). MS-ESI: [M+H]+ 195.1

後処理

  1. customThe system was evacuated
  2. additionrefilled with H2
  3. filtrationThe mixture was filtered
  4. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-06103eda935346e3bc37fdbb9bded099
出典データセット
uspto-grants-2014_05
特許番号
US08716274B2

反応ノート

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