Sodium Hydroxide → 2-(5-Bromo-4-fluoro-2-methylphenyl)acetic acid

HRID 1022386ノート

反応式

HRID 1022386 の反応式
C[O:2][C:3](=[O:14])[CH2:4][C:5]1[CH:10]=[C:9]([Br:11])[C:8]([F:12])=[CH:7][C:6]=1[CH3:13].[OH-].[Na+]>CO>[Br:11][C:9]1[C:8]([F:12])=[CH:7][C:6]([CH3:13])=[C:5]([CH2:4][C:3]([OH:14])=[O:2])[CH:10]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 59614585(5-Bromo-4-fluoro-2-methyl-phenyl)-acetic acid methyl ester

生成物 1

HCID 596146012-(5-Bromo-4-fluoro-2-methylphenyl)acetic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of (5-bromo-4-fluoro-2-methyl-phenyl)-acetic acid methyl ester (10.3 g) in methanol (50 ml) is added 1N aqueous sodium hydroxide (47.4 ml) and the reaction mixture is stirred at room temperature for 18 hours. The mixture is concentrated, the residue treated with 1N hydrochloric acid, the resulting precipitate filtered off, washed with ice-water and dried. Yield: 8.60 g of (5-bromo-4-fluoro-2-methyl-phenyl)-acetic acid as a solid, mp: 100-101° C.

後処理

  1. concentrationThe mixture is concentrated
  2. additionthe residue treated with 1N hydrochloric acid
  3. filtrationthe resulting precipitate filtered off
  4. washwashed with ice-water
  5. customdried

出典と根拠

ORDレコード
ord-c592fdb70c31478ba7cdc272fb3dffaa
出典データセット
uspto-grants-2014_05
特許番号
US08722578B2

反応ノート

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