Sodium Hydroxide → HCID 86663861、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[O:11][CH:10]2[C:12]([O:14]C)=[O:13])[CH:5]=[CH:6][C:7]=1[Cl:8].[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]2[O:11][CH:10]2[C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[Cl:8]参加物
4
実験手順
To a solution of methyl (2RS,3SR)-3-(3,4-dichlorophenyl)oxirane-2-carboxylate (90.9 g) in methanol (500 ml) was added 4 N sodium hydroxide solution (138 mL), and the mixture was stirred at room temperature for 2 hr. The reaction solution was filtered and washed with methanol. To the mother liquor was added 3 N hydrochloric acid (400 ml), and the mixture was stirred at room temperature for 1 hr. The resultant product was collected by filtration, and washed with distilled water to give the title compound (57.3 g).
後処理
- filtrationThe reaction solution was filtered
- washwashed with methanol
- additionTo the mother liquor was added 3 N hydrochloric acid (400 ml)
- stirringthe mixture was stirred at room temperature for 1 hr
- filtrationThe resultant product was collected by filtration
- washwashed with distilled water
出典と根拠
- ORDレコード
- ord-413b8b76fd204c33b7ec44d6d1870366
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08722662B2
反応ノート
読み込み中…