反応式
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][CH:7]1[CH:13]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=2)[O:12][CH2:11][CH2:10][N:9]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:8]1.C(N(CC)CC)C.O>C1COCC1>[Cl:21][C:16]1[CH:15]=[C:14]([CH:13]2[O:12][CH2:11][CH2:10][N:9]([C:22]([O:24][C:25]([CH3:27])([CH3:26])[CH3:28])=[O:23])[CH2:8][CH:7]2[NH:6][S:2]([CH3:1])(=[O:4])=[O:3])[CH:19]=[CH:18][C:17]=1[Cl:20]参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
Methanesulfonyl chloride (34 mg) was added to a solution of tert-butyl (6SR,7SR)-6-amino-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate (90 mg) and triethylamine (33 mg) in THF (5 mL), and the mixture was stirred at room temperature for 1 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (90 mg).
後処理
- extractionthe mixture was extracted with ethyl acetate
- washThe extract was washed with brine
- dry with materialdried over anhydrous sodium sulfate
- customThe solvent was evaporated under reduced pressure
- customThe residue was purified by silica gel column chromatography
出典と根拠
- ORDレコード
- ord-870da08f2e68436e8367b1e693122630
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08722662B2
関連ノート
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