Hydrochloric Acid → 2-(2-Pyridyloxy)acetic acid hydrochloride

HRID 1022732

反応式

HRID 1022732 の反応式
C([O:5][C:6](=[O:15])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)(C)(C)C.[ClH:16]>C1COCC1>[ClH:16].[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[O:8][CH2:7][C:6]([OH:15])=[O:5]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 46168743Tert-butyl(pyridin-2-yloxy)acetate

生成物 1

HCID 669759892-(2-Pyridyloxy)acetic acid hydrochloride

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of tert-butyl(pyridin-2-yloxy)acetate (0.18 g) in THF (1.5 mL) was added 6 mol/L hydrochloric acid (1.5 mL) at 0° C., and the mixture was warmed to room temperature, and stirred for 2 hr. The solvent was evaporated under reduced pressure, and the resultant solid was recrystallized from ethyl acetate and diisopropyl ether to give the title compound (0.11 g).

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. customthe resultant solid was recrystallized from ethyl acetate and diisopropyl ether

出典と根拠

ORDレコード
ord-f42aa198ffd049f88bb95d785cff233c
出典データセット
uspto-grants-2014_05
特許番号
US08722662B2

関連ノート

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