Hydrochloric Acid → 2-(2-oxopyrrolidin-1-yl)benzoic Acid
反応式
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=1[C:9]([O:11]CC)=[O:10].[OH-].[Na+].Cl>CO>[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=1[C:9]([OH:11])=[O:10]参加物
5
反応条件
- 温度
- 50 °C
実験手順
To a solution of ethyl 2-(2-oxopyrrolidin-1-yl)benzoate (4.3 g) in methanol (30 mL) was added 8 N aqueous sodium hydroxide solution (6.9 mL) at room temperature, and the mixture was heated to 50° C., and stirred overnight. The reaction mixture was allowed to cool to room temperature, and neutralized with 6 N aqueous hydrochloric acid solution (3 mL), and the solvent was evaporated under reduced pressure. The resultant crystals were recrystallized from ethanol to give the title compound (2.58 g).
後処理
- temperatureto cool to room temperature
- customthe solvent was evaporated under reduced pressure
- customThe resultant crystals were recrystallized from ethanol
出典と根拠
- ORDレコード
- ord-0f2945e56ef94efeb427b9c990ef3469
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08722662B2
反応ノート
読み込み中…