N-acetylanthranilic acid → 3-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-2-methylquinazolin-4(3H)-one monohydrochloride

HRID 1022772

反応式

HRID 1022772 の反応式
[NH2:1][CH2:2][C@H:3]1[C@H:9]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([F:17])[CH:11]=2)[O:8][CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[C:25]([NH:28][C:29]1[CH:37]=[CH:36][CH:35]=[CH:34][C:30]=1[C:31](O)=[O:32])(=O)[CH3:26]>>[ClH:16].[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C@@H:9]2[O:8][CH2:7][CH2:6][NH:5][CH2:4][C@H:3]2[CH2:2][N:1]2[C:31](=[O:32])[C:30]3[C:29](=[CH:37][CH:36]=[CH:35][CH:34]=3)[N:28]=[C:25]2[CH3:26])=[CH:11][C:12]=1[F:17]

参加物

3

反応物 2

HCID 6971N-acetylanthranilic acidHCID 66975002tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate

生成物 1

HCID 669767003-{[(6S,7R)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepan-6-yl]methyl}-2-methylquinazolin-4(3H)-one monohydrochloride

実験手順

Using tert-butyl (6R,7R)-6-(aminomethyl)-7-(4-chloro-3-fluorophenyl)-1,4-oxazepane-4-carboxylate and 2-(acetylamino)benzoic acid, and by a method similar to that of Example 39, the title compound was obtained.

出典と根拠

ORDレコード
ord-752753948b8e49edab6ff8b64c1b4bbd
出典データセット
uspto-grants-2014_05
特許番号
US08722662B2

関連ノート

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