Tetrabutylammonium Fluoride → methyl 4-fluoro-1H-indole-5-carboxylate
反応式
CCCC[N+](CCCC)(CCCC)CCCC.[F-].[F:19][C:20]1[C:28]([C:29]([O:31][CH3:32])=[O:30])=[CH:27][CH:26]=[C:25]2[C:21]=1[CH:22]=[CH:23][N:24]2[Si](C(C)C)(C(C)C)C(C)C>C1COCC1.CCOC(C)=O>[F:19][C:20]1[C:28]([C:29]([O:31][CH3:32])=[O:30])=[CH:27][CH:26]=[C:25]2[C:21]=1[CH:22]=[CH:23][NH:24]2参加物
5
実験手順
TBAF (1M solution in THF, 15.8 mmol, 15.8 mL) was added to a solution of compound 70b (7.9 mmol, 2.76 g) in THF at 0° C. After 10 min at room temperature, the reaction was diluted with EtOAc and washed with brine, saturated NaHCO3, and water. The organic layer was concentrated and purified by flash column chromatography (silica gel, 35% EtOAc/hexanes) to afford compound 70c.
後処理
- washwashed with brine, saturated NaHCO3, and water
- concentrationThe organic layer was concentrated
- custompurified by flash column chromatography (silica gel, 35% EtOAc/hexanes)
出典と根拠
- ORDレコード
- ord-dc759eb9a87f46088d676d0b8ec71a30
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08722658B2
反応ノート
読み込み中…