Sodium Hydroxide → 2-(2',3'-Dichloro[1,1'-biphenyl]-3-yl)propanedioic acid

HRID 1023284ノート

反応式

HRID 1023284 の反応式
C([O:3][C:4](=[O:25])[CH:5]([C:11]1[CH:12]=[C:13]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([Cl:23])[C:18]=2[Cl:24])[CH:14]=[CH:15][CH:16]=1)[C:6]([O:8]CC)=[O:7])C.[OH-].[Na+]>>[Cl:24][C:18]1[C:19]([Cl:23])=[CH:20][CH:21]=[CH:22][C:17]=1[C:13]1[CH:14]=[CH:15][CH:16]=[C:11]([CH:5]([C:4]([OH:25])=[O:3])[C:6]([OH:8])=[O:7])[CH:12]=1

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 669733992-(2',3'-Dichloro-[1,1'-biphenyl]-3-yl)propanedioic acid 1,3-diethyl ester2 回

生成物 1

HCID 669736132-(2',3'-Dichloro[1,1'-biphenyl]-3-yl)propanedioic acid

反応条件

温度
70 °C

実験手順

2-(2′,3′-Dichloro-[1,1′-biphenyl]-3-yl)propanedioic acid 1,3-diethyl ester (i.e. the product of Step B, 0.30 g, 0.79 mmol) was added to 2% aqueous sodium hydroxide (5 mL), and the reaction mixture was heated at 70° C. for 20 min. The reaction mixture was cooled, quenched with 6 N aqueous hydrochloric acid, and extracted with ethyl acetate. The organic layer was separated, washed with brine, dried over sodium sulfate, and concentrated under reduced pressure to yield the title compound (0.20 g).

後処理

  1. temperatureThe reaction mixture was cooled
  2. customquenched with 6 N aqueous hydrochloric acid
  3. extractionextracted with ethyl acetate
  4. customThe organic layer was separated
  5. washwashed with brine
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-01914ec508a6494a9a460b49abe1ee1a
出典データセット
uspto-grants-2014_05
特許番号
US08722690B2

反応ノート

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