[4-(2-Phenyl-2-o-tolyl-vinyl)-pyridin-2-yl]-urea → [4-(2-Phenyl-2-o-tolyl-ethyl)-pyridin-2-yl]-urea

HRID 1023439ノート

反応式

HRID 1023439 の反応式
[C:1]1([C:7]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[CH3:25])=[CH:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]([NH2:18])=[O:17])[CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H]>CO.C(Cl)Cl.[Pd]>[C:1]1([CH:7]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[CH3:25])[CH2:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH:15][C:16]([NH2:18])=[O:17])[CH:10]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

6

反応物 2

HCID 69083977[4-(2-Phenyl-2-o-tolyl-vinyl)-pyridin-2-yl]-ureaHCID 178418361HCID 178418361、化合物

生成物 1

HCID 69675800[4-(2-Phenyl-2-o-tolyl-ethyl)-pyridin-2-yl]-urea収率 14%

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 6344Dichloromethane溶媒

実験手順

[4-(2-Phenyl-2-o-tolyl-vinyl)-pyridin-2-yl]-urea (140 mg, 0.43 mmol) is dissolved in methanol (2 mL) and DCM (2 mL). Then 5% palladium on carbon (90 mg, 0.043 mmol) is added. The reaction is stirred for 16 hours under the hydrogen atmosphere. The palladium on carbon is filtered and the filtrate is concentrated to give the crude product. Purification by Gilson preparative HPLC affords 20 mg of the titled product.

後処理

  1. filtrationThe palladium on carbon is filtered
  2. concentrationthe filtrate is concentrated
  3. customto give the crude product
  4. customPurification by Gilson preparative HPLC

出典と根拠

ORDレコード
ord-d68d4513a52846dc93f7ff3d5378bc9d
出典データセット
uspto-grants-2014_05
特許番号
US08722709B2

反応ノート

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