4-[2-(4-Fluoro-phenyl)-cyclohex-1-enyl]-pyridin-2-ylamine → 4-[cis-2-(4-Fluoro-phenyl)-cyclohexyl]-pyridin-2-ylamine

HRID 1023473ノート

反応式

HRID 1023473 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[C:14]2[CH:19]=[CH:18][N:17]=[C:16]([NH2:20])[CH:15]=2)=[CH:4][CH:3]=1.[H][H]>CO.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C@H:8]2[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]2[C:14]2[CH:19]=[CH:18][N:17]=[C:16]([NH2:20])[CH:15]=2)=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 690855804-[2-(4-Fluoro-phenyl)-cyclohex-1-enyl]-pyridin-2-ylamineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 690841454-[cis-2-(4-Fluoro-phenyl)-cyclohexyl]-pyridin-2-ylamine収率 54.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 4-[2-(4-Fluoro-phenyl)-cyclohex-1-enyl]-pyridin-2-ylamine (220 mg, 0.82 mmol, synthesis described in example 56) in methanol (10 mL) is passed through H-Cube® Continuous-flow Hydrogenation Reactor at 60° C. and under 60 psi hydrogen pressure. The 10% Pd/C cartridge is used and the reaction is run for 48 hours. The solvent is removed to give 120 mg of the desired product.

後処理

  1. customThe solvent is removed

出典と根拠

ORDレコード
ord-3e7c8eb1a2fa41b0ab68a1f44c4c4fcd
出典データセット
uspto-grants-2014_05
特許番号
US08722709B2

反応ノート

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