HCID 67235239、化合物 → HCID 67235719、化合物

HRID 1023526ノート

反応式

HRID 1023526 の反応式
[CH3:1][CH:2]([O:4][C:5]1[CH:6]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][N:13]=2)[CH:8]=[CH:9][CH:10]=1)[CH3:3]>CO.[Pd]>[CH3:3][CH:2]([O:4][C:5]1[CH:6]=[C:7]([O:11][C:12]2[N:13]=[CH:14][C:15]([NH2:18])=[CH:16][CH:17]=2)[CH:8]=[CH:9][CH:10]=1)[CH3:1]

参加物

4

反応物 1

HCID 67235239HCID 67235239、化合物2 回

生成物 1

HCID 67235719HCID 67235719、化合物収率 93.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 2-({3-[(1-methylethyl)oxy]phenyl}oxy)-5-nitropyridine (Intermediate 28, 670 mg, 2.45 mmol) in methanol (50 mL) was added Pd/C (10%, 100 mg, 0.1 wet. e.q.) and the flask was filled in with H2. The resulting mixture was stirred at room temperature under H2 atmosphere overnight and filtered. The filtrate was concentrated under vacuum to afford the title compound as a brown solid (560 mg).

後処理

  1. additionthe flask was filled in with H2
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated under vacuum

出典と根拠

ORDレコード
ord-de9fad0f9aa641928311a8992030f327
出典データセット
uspto-grants-2014_05
特許番号
US08722695B2

反応ノート

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