Trifluoroacetic acid → HCID 67235885、化合物

HRID 1023542ノート

反応式

HRID 1023542 の反応式
CC([N:5]([C@H:9]([CH3:29])[C:10]([NH:12][C:13]1[CH:14]=[N:15][C:16]([O:19][C:20]2[CH:25]=[CH:24][C:23]([CH3:26])=[C:22]([O:27][CH3:28])[CH:21]=2)=[CH:17][CH:18]=1)=[O:11])C(=O)[O-])(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH3:26][C:23]1[CH:24]=[CH:25][C:20]([O:19][C:16]2[N:15]=[CH:14][C:13]([NH:12][C:10](=[O:11])[C@@H:9]([CH3:29])[NH2:5])=[CH:18][CH:17]=2)=[CH:21][C:22]=1[O:27][CH3:28]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 866735881,1-dimethylethyl{(1R)-1-methyl-2-[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]-2-oxoethyl}carbamate2 回

生成物 1

HCID 67235885HCID 67235885、化合物収率 98%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 1,1-dimethylethyl{(1R)-1-methyl-2-[(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)amino]-2-oxoethyl}carbamate (Intermediate 51, 350 mg) in dry dichloromethane (7.5 mL), TFA (2.5 mL, 32.4 mmol) was slowly added and the reaction mixture was stirred for 1.5 hours at room temperature. The solvent and the excess of TFA were evaporated and the residue was purified with an SCX cartridge (10 g) to afford the title compound as a colourless oil (258 mg).

後処理

  1. customThe solvent and the excess of TFA were evaporated
  2. customthe residue was purified with an SCX cartridge (10 g)

出典と根拠

ORDレコード
ord-397dd9b82e3549b782123c758421e982
出典データセット
uspto-grants-2014_05
特許番号
US08722695B2

反応ノート

読み込み中…