Trifluoroacetic acid → HCID 67235286、化合物
反応式
CC([N:5]([C@@H:9]([C:13]([NH:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][C:23]2[CH:28]=[CH:27][C:26]([CH3:29])=[C:25]([O:30][CH3:31])[CH:24]=2)=[CH:18][CH:17]=1)=[O:14])[CH:10]([CH3:12])[CH3:11])C(=O)[O-])(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH3:29][C:26]1[CH:27]=[CH:28][C:23]([O:22][C:19]2[CH:20]=[CH:21][C:16]([NH:15][C:13](=[O:14])[C@@H:9]([CH:10]([CH3:12])[CH3:11])[NH2:5])=[CH:17][CH:18]=2)=[CH:24][C:25]=1[O:30][CH3:31]参加物
4
実験手順
To a solution of 1,1-dimethylethyl((1R)-2-methyl-1-{[(4-{[4-methyl-3-(methyloxy)phenyl]oxy}phenyl)amino]carbonyl}propyl)carbamate (Intermediate 82, 110 mg) in dry dichloromethane (3 mL), TFA (1 mL, 12.98 mmol) was added and the reaction mixture was stirred for 1 hour at room temperature. The solvent and the excess of TFA were evaporated and the residue was purified by SCX cartridge (5 g) to afford the title compound as a yellow pale solid (68 mg).