HCID 178458286、化合物 → HCID 178458287、化合物
反応式
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([C:10](=[CH2:24])[CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]2[N:20]=[CH:21][NH:22][CH:23]=2)=[CH:2]1>CO.[Pd]>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH:10]([CH3:24])[CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[C:19]2[N:20]=[CH:21][NH:22][CH:23]=2)=[CH:2]1参加物
4
実験手順
To a solution of 4-(2-((2-(benzofuran-3-yl)allyl)oxy)phenyl)-1H-imidazole (0.126 mmol) in MeOH (3 mL) at room temperature was added 10% Pd/C (0.019 mmol) and the mixture was flushed with hydrogen gas after evacuating under vacuum. After stirring overnight the solution was filtered through a celite bed and the solvent was evaporated under reduced pressure to afford the crude product. Chromatographic purification afforded the final product. Yield 75%. 1H NMR: 1.55 (d, 3H, J=5.22 Hz), 3.60 (m, 1H), 4.36 (m, 2H), 7.01 (t, 2H J=5.97 Hz), 7.19-7.36 (m, 5H), 7.38 (s, 1H), 7.53 (d, 1H, J=6.09 Hz), 7.58 (s, 1H), 7.64 (d, 1H, J=5.76 Hz), 7.75 (d, 1H, J=5.01 Hz)