Methanol → 4-Methoxy-1H-pyrrolo[2,3-b]pyridine

反応式

Cl[C:2]1[CH:10]=[CH:9][N:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][NH:6]2.[OH-:11].[Na+].[CH3:13]O>>[CH3:13][O:11][C:2]1[CH:10]=[CH:9][N:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][NH:6]2

参加物

反応物 3

HCID 887Methanol

HCID 14798Sodium Hydroxide

HCID 113894934-Chloro-1H-pyrrolo[2,3-b]pyridine

生成物 1

HCID 112405674-Methoxy-1H-pyrrolo[2,3-b]pyridine

実験手順

4-methoxy-7-azaindole 20 was prepared by reacting 4-chloro-7-azaindole 24 (prepared as described in Example 9) with sodium hydroxide in methanol as described by Girgis, N. et.al., J. Heterocyclic. Chem. 1989, 26:317-325.

出典と根拠

ORDレコード: ord-28110570a83b404f8e2cf6d098bb31a0
出典データセット: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08722702B2

反応ノート

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