Sodium borohydride → 3-Chloro-1-(2-thienyl)-1-propanol

HRID 1024482ノート

反応式

HRID 1024482 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[O:10])[CH2:7][CH2:8][Cl:9].[BH4-].[Na+]>C(O)C>[Cl:9][CH2:8][CH2:7][CH:6]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[OH:10]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 75678553-Chloro-1-(2-thienyl)-1-propanone

生成物 1

HCID 116583743-Chloro-1-(2-thienyl)-1-propanol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

For example, a method is known wherein 1-(2-thienyl)-3-chloropropan-1-one is reduced using sodium borohydride in ethanol to obtain 3-chloro-1-(2-thienyl)-1-propanol, halogen exchange is subsequently conducted in acetone using sodium iodide to obtain 3-iodo-1-(2-thienyl)-1-propanol, and then this is reacted with a monomethylamine aqueous solution in tetrahydrofuran (CHIRALITY, 12, 26-29 (2000)). However, since the raw material used in this method is 1-(2-thienyl)-3-chloropropan-1-one, which is a very unstable compound, this method is not industrially applicable.

出典と根拠

ORDレコード
ord-4468c15f9511432f9b12f9e957049382
出典データセット
uspto-grants-2014_05
特許番号
US08722906B2

反応ノート

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