Benzyl isocyanide → (2S,3S)-3-Amino-N-benzyl-2-hydroxyhexanamide dihydrochloride

反応式

[ClH:1].Cl.N[C@@H](CC)[C@H](O)C(NC1CC1)=[O:7].[NH2:15][C@@H:16]([CH2:19][CH2:20][CH3:21])[CH2:17][OH:18].[N+:22]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)#[C-:23]>>[ClH:1].[ClH:1].[NH2:15][C@@H:16]([CH2:19][CH2:20][CH3:21])[C@H:17]([OH:18])[C:23]([NH:22][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:7]

参加物

反応物 3

HCID 82558Benzyl isocyanide

HCID 6951248(2S)-2-aminopentan-1-ol

HCID 86762404(2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide dihydrochloride

生成物 1

HCID 86762417(2S,3S)-3-Amino-N-benzyl-2-hydroxyhexanamide dihydrochloride

実験手順

The title compound was prepared in analogy to (2S,3S)-3-amino-N-cyclopropyl-2-hydroxypentanamide dihydrochloride, Representative Procedure A, starting with (S)-2-aminopentan-1-ol in the first step (A1), and using (isocyanomethyl)benzene in the third step (A3).

出典と根拠

ORDレコード: ord-a4f4ee43b3bf4029b8a64d99107f366a
出典データセット: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08729061B2

反応ノート

読み込み中…

参加物