3-(azepan-1-yl)-N-benzyl-N-methylpropan-1-amine → 3-(Azepan-1-yl)-N-methylpropan-1-amine
反応式
[N:1]1([CH2:8][CH2:9][CH2:10][N:11](CC2C=CC=CC=2)[CH3:12])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>CO.[Pd]>[N:1]1([CH2:8][CH2:9][CH2:10][NH:11][CH3:12])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
5
実験手順
3-(Azepan-1-yl)-N-benzyl-N-methylpropan-1-amine (100 mg) was dissolved in MeOH (20 mL) and to the solution was added 10% Pd/C (50 mg). The reaction mixture was shook under 50 psi hydrogen atmosphere for 2 h. The catalyst was filtered over Cellite and washed with methanol. The filtrated was evaporated to give 3-(azepan-1-yl)-N-methylpropan-1-amine, used without further purification.
後処理
- filtrationThe catalyst was filtered over Cellite
- washwashed with methanol
- customThe filtrated was evaporated
出典と根拠
- ORDレコード
- ord-0cee089173a14ebd94458429875714a0
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08729081B2
反応ノート
読み込み中…