Trifluoroacetic acid → 3-(Azepan-1-yl)propan-1-amine
反応式
[N:1]1([CH2:8][CH2:9][CH2:10][N:11]2C(=O)C3C(=CC=CC=3)C2=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.NN.C(O)(C(F)(F)F)=O>C(O)C>[N:1]1([CH2:8][CH2:9][CH2:10][NH2:11])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
5
実験手順
To a solution of 2-(3-(azepan-1-yl)propyl)isoindoline-1,3-dione (3.5 g) in Ethanol (20 mL) was added hydrazine (0.58 mL). The reaction mixture was reflux for 13 h and then cooled down to room temperature. TFA (2.0 mL) was added, the resulted white solid was filtered and the solvent was evaporated to give 3-(azepan-1-yl)propan-1-amine, used without further purification.
後処理
- temperatureThe reaction mixture was reflux for 13 h
- filtrationthe resulted white solid was filtered
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-a96ef221609240c7a545a00ae414c4b8
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08729081B2
反応ノート
読み込み中…