Ammonia → 3-Chloro-6,7-dimethyl-quinoxalin-2-ylamine
反応式
[Cl:1][C:2]1[C:11](Cl)=[N:10][C:9]2[C:4](=[CH:5][C:6]([CH3:14])=[C:7]([CH3:13])[CH:8]=2)[N:3]=1.C(=O)=O.[NH3:18]>C1COCC1>[Cl:1][C:2]1[C:11]([NH2:18])=[N:10][C:9]2[C:4]([N:3]=1)=[CH:5][C:6]([CH3:14])=[C:7]([CH3:13])[CH:8]=2参加物
5
反応条件
- 温度
- 100 °C
実験手順
A mixture of 2,3-dichloro-6,7-dimethyl-quinoxaline (30 g) in 300 mL of THF was cooled with dry-ice in a sealed vessel. Ammonia gas was added for 10 min, then the mixture was heated to 100° C. for 20 h. After removal of the solvent in vaccuo the residue was purified by flash chromatography to yield 14 g of the title compound. 1H-NMR (300 MHz, d6-DMSO): δ=7.43 (1H, s), 7.37 (1H, s), 7.00 (2H, s), 2.28 (6H, s) ppm.
後処理
- customAfter removal of the solvent in vaccuo the residue
- customwas purified by flash chromatography
出典と根拠
- ORDレコード
- ord-ac1cc7516bbc4f06a12ba5cae3ed3853
- 出典データセット
- uspto-grants-2014_05
- 特許番号
- US08729082B2
反応ノート
読み込み中…