Trifluoroacetic acid → 4-(5-Bromo-2-methyl-2,3-dihydrobenzofuran-2-yl)piperidine

反応式

[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH:11]3[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]3)([CH3:10])[CH2:7][C:6]=2[CH:24]=1.C(O)(C(F)(F)F)=O.FC1C2OC(C3(O)CCN(C4N=CC(CCC)=CN=4)CC3)CC=2C=C(C2CCNCC=2)C=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)([CH3:10])[CH2:7][C:6]=2[CH:24]=1

参加物

反応物 3

HCID 6422Trifluoroacetic acid

HCID 674657764-(7-Fluoro-5-(1,2,3,6-tetrahydropyridin-4-yl)-2,3-dihydrobenzofuran-2-yl)-1-(5-propylpyrimidin-2-yl)piperidin-4-ol

HCID 68211517tert-Butyl 4-(5-bromo-2-methyl-2,3-dihydrobenzofuran-2-yl)piperidine-1-carboxylate

生成物 1

HCID 674657574-(5-Bromo-2-methyl-2,3-dihydrobenzofuran-2-yl)piperidine

実験手順

Compound 11D was prepared from Compound 11C and TFA in a similar manner to the procedure described for Compound 1J in Example 1. LC/MS (m/z)=296 (M+H)+.

出典と根拠

ORDレコード: ord-c0918c4f6fe349bbb53ecd9adc5be44e
出典データセット: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08729084B2

反応ノート

読み込み中…

参加物

反応物 3

HCID 6422Trifluoroacetic acid

HCID 674657764-(7-Fluoro-5-(1,2,3,6-tetrahydropyridin-4-yl)-2,3-dihydrobenzofuran-2-yl)-1-(5-propylpyrimidin-2-yl)piperidin-4-ol

HCID 68211517tert-Butyl 4-(5-bromo-2-methyl-2,3-dihydrobenzofuran-2-yl)piperidine-1-carboxylate

生成物 1

HCID 674657574-(5-Bromo-2-methyl-2,3-dihydrobenzofuran-2-yl)piperidine

実験手順

Compound 11D was prepared from Compound 11C and TFA in a similar manner to the procedure described for Compound 1J in Example 1. LC/MS (m/z)=296 (M+H)+.

出典と根拠

ORDレコード: ord-c0918c4f6fe349bbb53ecd9adc5be44e
出典データセット: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08729084B2

反応ノート

読み込み中…